Particle Targeting: Particle Targeting in Complex Biological Media (Adv. Healthcare Mater. 1/2018)
نویسندگان
چکیده
منابع مشابه
Particle size, magnetic field, and blood velocity effects on particle retention in magnetic drug targeting.
PURPOSE A physics-based model of a general magnetic drug targeting (MDT) system was developed with the goal of realizing the practical limitations of MDT when electromagnets are the source of the magnetic field. METHODS The simulation tracks magnetic particles subject to gravity, drag force, magnetic force, and hydrodynamic lift in specified flow fields and external magnetic field distributio...
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Signal recognition particle (SRP) plays a central role in the delivery of classical secretory and membrane proteins to the endoplasmic reticulum (ER). All nascent chains studied to date dissociate from SRP once released from the ribosome, thereby supporting a strictly cotranslational mode of action for eukaryotic SRP. We now report a novel post-translational function for SRP in the targeting of...
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Accurate folding, assembly, localization, and maturation of newly synthesized proteins are essential to all cells and require high fidelity in the protein biogenesis machineries that mediate these processes. Here, we review our current understanding of how high fidelity is achieved in one of these processes, the cotranslational targeting of nascent membrane and secretory proteins by the signal ...
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ژورنال
عنوان ژورنال: Advanced Healthcare Materials
سال: 2018
ISSN: 2192-2640
DOI: 10.1002/adhm.201870004